Activity of Minocycline Against R Factor-Carrying Enterobacteriaceae

Activity of Meropenem-Vaborbactam Against Enterobacteriaceae Isolates Carrying blaKPC Collected Worldwide

Immunogenicity of R factor-carrying Salmonella.

An increased frequency of rough cultures with associated reductions in mouse virulence was detected after R-factor transmission into strains of Salmonella choleraesuis var. kunzendorf and S. typhimurium. All rough strains tested, with or without R factors, conferred protective immunity against challenge with homologous or heterologous species of Salmonella, some of which contained R factors. Al...

Activity of faropenem against cephalosporin-resistant Enterobacteriaceae.

BACKGROUND There is a need for new oral agents active against extended-spectrum beta-lactamase (ESBL) producers, as these increasingly cause community-onset infections. We therefore evaluated faropenem, a penem in Phase III development, against recently collected oxyimino-cephalosporin-resistant bacteria. METHODS We tested 847 consecutive cephalosporin-resistant Enterobacteriaceae collected a...

Antimicrobial Activity of Minocycline against Bacteria and Fungi

Minocycline is a semi-synthetic tetracycline derivative and appears to be as effective as other tetracyclines and analogues. The present research work is on anti-microbial assay to demonstrate the minocycline is more effective on selected gram-positive than the gram-negative bacterial strains. It showed the highest zone of inhibition on Bacillus subtilis than Staphylococccu aureus when cultured...

Activity of minocycline against Toxoplasma gondii infection in mice.

The chemotherapeutic activity of minocycline, a semi-synthetic tetracycline analogue, was evaluated in a murine model of toxoplasmosis. A lethal acute toxoplasmosis was produced by injecting 10(5) tachyzoites of the RH strain of Toxoplasma gondii into the peritoneal cavities of Swiss-Webster mice. When infected mice were treated once daily for 12 days, starting 2 h after challenge, the survival...